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Reference
Determining the Error of Dose Estimates and Minimum and Maximum Acceptable Concentrations from Assay with Nonlinear Dose-Response Curves, Gottschalk PG, Dunn JR, Computer Methods and Programs in Biomedicine, 2005; 80:204-215. (Free Reprint Available)
Statistical Assay Analysis
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Statistical Assay Analysis measures the performance of all immunoassay components: pipetting, separation, label, tracer, antibody, buffer, incubation, standards, controls, and unknowns |
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StatLIA stores each acceptable assay as it’s run on StatLIA to use as a pool of historical reference assays for statistical comparisons to detect changes in reagents or incubation conditions |
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The laboratory controls which assays are used as the final pool of reference assays; (unless changed by the laboratory, the first 30 acceptable assays are used by default) |
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Statistical comparisons are made between each control parameter in today's assay and the same parameter in the historical reference assays |
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For example, the response of each standard in today’s assay is compared to each corresponding standard’s responses in the reference assays |
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A statistical comparison is made to determine whether the responses (and all other parameters) are significantly different from their corresponding parameters in the reference assays |
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Some of the parameters StatLIA analyzes include standard responses, control specimen responses and concentrations, curve fit statistics, ED 20/50/80, min/max detectable concentrations, and more |
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